Pharmacology of testosterone replacement therapy preparations

Testosterone Depo-Testosterone, Xyosted, and others: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Testosterone may also be used for other conditions as determined by your health care provider. Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates, but may cause disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor. Finally, in the present analysis it was attempted to select those studies of testosterone treatment that provided adequate doses/delivery of testosterone.

Although this new information is somewhat reassuring, men and their doctors should still weigh these issues before committing to long term testosterone therapy. Whether you’re seeking to enhance muscle growth, increase energy, or improve overall mood, understanding the differences between these two compounds is crucial. In this comprehensive guide, we’ll dive deep into the advantages and drawbacks of Testosterone Enanthate versus Cypionate, helping you make an informed decision that aligns with your fitness goals. When it comes to optimizing your testosterone levels, choosing the right ester can make all the difference. Testosterone Enanthate and Testosterone Cypionate are two of the most popular options available, each boasting unique characteristics that cater to individual needs.

Testosterone is in a class of medications called androgenic hormones. Testosterone is a hormone produced by the body that contributes to the growth, development, and functioning of the male sexual organs and typical male characteristics. Testosterone injection works by supplying synthetic testosterone to replace the testosterone that is normally produced naturally in the body. When used to treat breast cancer, testosterone works by stopping the release of estrogen. A multi-center, prospective randomized trial compared the PKs, efficacy, and safety of the transdermal system to IM testosterone enanthate (TE) injections (25). Treatment was for 24 weeks and 33 subjects were enrolled per group. For the transdermal system group, the starting dose was 5 mg/day (2×2.5 mg/day patches, no longer commercially available).

The patient experiences, to his satisfaction, profound changes in his physical appearance and his mental makeup. The attending physician observes the changes the patient undergoes and rarely fails to be fascinated by the multitude of functions testosterone appears to have in the process of masculinization in the broadest sense (1). Talk with your doctor about other drug options that may work for you. Testosterone cypionate is given by injection into a muscle (usually the buttocks).

Both options are supplied in 100 mg/mL (10 mL) and 200 mg/mL (1 and 10 mL) concentrations, prepared in cottonseed oil. The USA FDA recommended starting dose for male hypogonadism is 50 to 400 mg IM every 2 to 4 weeks (41). The Endocrine Society Clinical Practice Guidelines for testosterone therapy suggest an alternative of either 75 to 100 mg IM weekly or 150 to 200 mg IM every 2 weeks (3). The efficacy of the transdermal patch is often limited by lack of adherence or discontinuation due to skin blistering, pruritus, or irritation. This is due to permeation enhancers included in the transdermal system which are necessary to increase absorption.

Testosterone was in use in 1938 and approved by the FDA in 1939. Anabolic steroids, derivatives of testosterone, have been used illicitly and are now controlled substances. Testosterone, like many anabolic steroids, was classified as a controlled substance in 1991. Testosterone is administered parenterally in regular and delayed-release (depot) dosage forms. In September 1995, the FDA initially approved testosterone transdermal patches (Androderm); many transdermal forms and brands are now available including implants, gels, and topical solutions. A testosterone buccal system, Striant, was FDA approved in July 2003; the system is a mucoadhesive product that adheres to the buccal mucosa wild yams and testosterone provides a controlled and sustained release of testosterone. In May 2014, the FDA approved an intranasal gel formulation (Natesto).

Most insurance plans put testosterone cypionate in their lowest copay tiers, though some plans place the injection in higher copay tiers. Adverse effects were reported from a controlled clinical study where 304 patients were treated with Testim® 50 mg, 100 mg or placebo up to 90 days (33). The only reported adverse effect with greater than 3% incidence was application site reactions at 4% in the 100 mg group.

An increase in prostate volume was noted after 3 months (86) and after 12 months (44). One study over 24 months found no significant increase in both PSA and prostate volume. In a study of 81 hypogonadal men (mean age 56.8 years) followed for a mean (range) of 33.8 (6–144) months PSA levels did not increase significantly at 1-year intervals for 5 years (88). Testosterone Enanthate is widely used in testosterone replacement therapy (TRT) to restore hormone levels in individuals with hypogonadism or age-related testosterone decline.

Do not share this medicine with anyone who has not been prescribed this medicine. Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine. Keep all appointments for medical exams and tests while on this medicine. If the liquid medicine has any particles in it, appears discolored, or if the vial appears damaged, do not use it. Read and make sure you understand the instructions for measuring your dose and using the syringe before using this medicine.